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Target
RNA-directed RNA polymerase
Ligand
BDBM50162105
Substrate
n/a
Meas. Tech.
ChEMBL_306530 (CHEMBL829597)
IC50
11±n/a nM
Citation
 Harper, S; Pacini, B; Avolio, S; Di Filippo, M; Migliaccio, G; Laufer, R; De Francesco, R; Rowley, M; Narjes, F Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase. J Med Chem 48:1314-7 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50162105
Synonyms:
3-Cyclohexyl-1-(2-morpholin-4-yl-2-oxo-ethyl)-2-p-tolyl-1H-indole-6-carboxylic acid | CHEMBL179228
Type:
Small organic molecule
Emp. Form.:
C28H32N2O4
Mol. Mass.:
460.5647
SMILES:
Cc1ccc(cc1)-c1c(C2CCCCC2)c2ccc(cc2n1CC(=O)N1CCOCC1)C(O)=O
Structure:
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