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Target
Tryptase beta-2
Ligand
BDBM50162760
Substrate
n/a
Meas. Tech.
ChEMBL_304961 (CHEMBL827839)
IC50
4400±n/a nM
Citation
del Fresno, M; Fernández-Forner, D; Miralpeix, M; Segarra, V; Ryder, H; Royo, M; Albericio, F Combinatorial approaches towards the discovery of new tryptase inhibitors. Bioorg Med Chem Lett 15:1659-64 (2005) [PubMed] Article
More Info.:
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Inhibitor
Name:
BDBM50162760
Synonyms:
4-Guanidino-N-[(S)-4-((S)-5-{4-[2-(2-imino-imidazolidin-1-yl)-acetylamino]-butyl}-3,6-dioxo-piperazin-2-yl)-butyl]-benzamide | CHEMBL362598
Type:
Small organic molecule
Emp. Form.:
C25H38N10O4
Mol. Mass.:
542.6338
SMILES:
[#7]\[#6](-[#7])=[#7]/c1ccc(cc1)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#7]-2-[#6]-[#6]-[#7]=[#6]-2-[#7])-[#7]-[#6]-1=O |c:34|