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Target
Tryptase beta-2
Ligand
BDBM50162764
Substrate
n/a
Meas. Tech.
ChEMBL_304961 (CHEMBL827839)
IC50
4100±n/a nM
Citation
del Fresno, M; Fernández-Forner, D; Miralpeix, M; Segarra, V; Ryder, H; Royo, M; Albericio, F Combinatorial approaches towards the discovery of new tryptase inhibitors. Bioorg Med Chem Lett 15:1659-64 (2005) [PubMed] Article
More Info.:
Target
Name:
Tryptase beta-2
Synonyms:
TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2
Type:
PROTEIN
Mol. Mass.:
30518.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_210702
Residue:
275
Sequence:
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Inhibitor
Name:
BDBM50162764
Synonyms:
CHEMBL359680 | [1-((S)-4-{(S)-5-[4-((S)-(S)-2-Benzyloxycarbonylamino-5-guanidino-pentanoylamino)-butyl]-6-oxo-3-oxo-piperazin-2-yl}-butylcarbamoyl)-4-guanidino-butyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C40H60N12O8
Mol. Mass.:
836.98
SMILES:
NC(=N)NCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc2ccccc2)NC1=O