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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50163379
Substrate
n/a
Meas. Tech.
ChEMBL_300364 (CHEMBL840342)
Kd
0.100000±n/a nM
Citation
 Surleraux, DL; de Kock, HA; Verschueren, WG; Pille, GM; Maes, LJ; Peeters, A; Vendeville, S; De Meyer, S; Azijn, H; Pauwels, R; de Bethune, MP; King, NM; Prabu-Jeyabalan, M; Schiffer, CA; Wigerinck, PB Design of HIV-1 protease inhibitors active on multidrug-resistant virus. J Med Chem 48:1965-73 (2005) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50163379
Synonyms:
((1S,2R)-1-Benzyl-2-hydroxy-3-{isobutyl-[2-(2-pyrrolidin-1-yl-ethylamino)-benzothiazole-6-sulfonyl]-amino}-propyl)-carbamic acid (3R,3aS,6aR)-(hexahydro-furo[2,3-b]furan-3-yl) ester | CHEMBL436082
Type:
Small organic molecule
Emp. Form.:
C34H47N5O7S2
Mol. Mass.:
701.896
SMILES:
CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)c1ccc2nc(NCCN3CCCC3)sc2c1
Structure:
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