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Target
Serine/threonine-protein kinase PAK 6
Ligand
BDBM50429615
Substrate
n/a
Meas. Tech.
ChEMBL_2198934 (CHEMBL5111450)
IC50
60±n/a nM
Citation
 Drewry, DH; Potjewyd, FM; Bayati, A; Smith, JL; Dickmander, RJ; Howell, S; Taft-Benz, S; Min, SM; Hossain, MA; Heise, M; McPherson, PS; Moorman, NJ; Axtman, AD Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of ?-Coronaviruses. J Med Chem 65:12860-12882 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase PAK 6
Synonyms:
PAK5 | PAK6 | PAK6_HUMAN | Serine/threonine-protein kinase PAK5 | Serine/threonine-protein kinase PAK6
Type:
PROTEIN
Mol. Mass.:
74897.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513397
Residue:
681
Sequence:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
  
Inhibitor
Name:
BDBM50429615
Synonyms:
CHEMBL2334586
Type:
Small organic molecule
Emp. Form.:
C20H20N4O
Mol. Mass.:
332.399
SMILES:
CC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Structure:
Search PDB for entries with ligand similarity: