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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM136516
Substrate
n/a
Meas. Tech.
ChEMBL_2200840 (CHEMBL5113356)
IC50
134±n/a nM
Citation
 Murakami, Y; Osawa, H; Kurohara, T; Yanase, Y; Ito, T; Yokoo, H; Shibata, N; Naito, M; Aritake, K; Demizu, Y Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D RSC Med Chem 13:1495-1503 (2022) [PubMed] 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM136516
Synonyms:
US8865714, 3
Type:
Small organic molecule
Emp. Form.:
C27H36N6O4
Mol. Mass.:
508.6125
SMILES:
Cn1cccc1C(=O)N1CCN(CC1)C(=O)Nc1ccc(cc1)N1CCC(CC1)C(=O)N1CCOCC1
Structure:
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