Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 2
Ligand
BDBM50164245
Substrate
n/a
Meas. Tech.
ChEMBL_302592 (CHEMBL839552)
Ki
>3000±n/a nM
Citation
McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem 48:2274-7 (2005) [PubMed] Article
More Info.:
Target
Name:
Melanin-concentrating hormone receptor 2
Synonyms:
GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38862.16
Organism:
Homo sapiens (Human)
Description:
Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1
Residue:
340
Sequence:
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
Inhibitor
Name:
BDBM50164245
Synonyms:
1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(3,5-dichloro-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-urea | CHEMBL372721
Type:
Small organic molecule
Emp. Form.:
C26H28Cl2N4O
Mol. Mass.:
483.433
SMILES:
Clc1cc(Cl)cc(NC(=O)N(CCN2CCCC2)[C@@H]2CC[C@@]3(C[C@H]23)c2ccc(cc2)C#N)c1