Reaction Details Report a problem with these data
Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50266958
Substrate
n/a
Meas. Tech.
ChEMBL_2201132 (CHEMBL5113840)
IC50
10210±n/a nM
Citation
 Negi, A; Murphy, PV Development of Mcl-1 inhibitors for cancer therapy. Eur J Med Chem 210:0 (2021) [PubMed] 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50266958
Synonyms:
CHEMBL4077940
Type:
Small organic molecule
Emp. Form.:
C29H34N4O7
Mol. Mass.:
550.6029
SMILES:
CC(C)Oc1cc(ccc1N)C(=O)Nc1ccc(nc1OC(C)C)C(=O)Nc1ccc(cc1OC(C)C)C(O)=O
Structure:
Search PDB for entries with ligand similarity: