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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50591662
Substrate
n/a
Meas. Tech.
ChEMBL_2201139 (CHEMBL5113847)
Ki
11400±n/a nM
Citation
 Negi, A; Murphy, PV Development of Mcl-1 inhibitors for cancer therapy. Eur J Med Chem 210:0 (2021) [PubMed] 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50591662
Synonyms:
CHEMBL5208863
Type:
Small organic molecule
Emp. Form.:
C25H40O8
Mol. Mass.:
468.5803
SMILES:
[H][C@]12O[C@]11[C@@H](CC[C@H](C)[C@@]1(C)C[C@@]1([H])C(=O)CO[C@@]21O)OC(=O)C(O)(CO)CC(C)CC(C)CC |r|
Structure:
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