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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50308111
Substrate
n/a
Meas. Tech.
ChEMBL_2201162 (CHEMBL5113870)
Ki
8000±n/a nM
Citation
 Negi, A; Murphy, PV Development of Mcl-1 inhibitors for cancer therapy. Eur J Med Chem 210:0 (2021) [PubMed] 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50308111
Synonyms:
(S,Z)-2-(5-((6-(3,4-dimethoxyphenyl)pyridin-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid | CHEMBL596599
Type:
Small organic molecule
Emp. Form.:
C26H22N2O5S2
Mol. Mass.:
506.593
SMILES:
COc1ccc(cc1OC)-c1ccc(\C=C2/SC(=S)N([C@@H](Cc3ccccc3)C(O)=O)C2=O)cn1 |r|
Structure:
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