Reaction Details Report a problem with these data
Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50591666
Substrate
n/a
Meas. Tech.
ChEMBL_2201162 (CHEMBL5113870)
Ki
7770±n/a nM
Citation
 Negi, A; Murphy, PV Development of Mcl-1 inhibitors for cancer therapy. Eur J Med Chem 210:0 (2021) [PubMed] 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50591666
Synonyms:
CHEMBL5207001
Type:
Small organic molecule
Emp. Form.:
C21H24ClNO5S
Mol. Mass.:
437.937
SMILES:
Cc1cc(OCCCS(=O)(=O)N2CC(Cc3ccccc23)C(O)=O)cc(C)c1Cl
Structure:
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