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Target
Bcl-2 homologous antagonist/killer
Ligand
BDBM50591668
Substrate
n/a
Meas. Tech.
ChEMBL_2201162 (CHEMBL5113870)
Ki
153±n/a nM
Citation
 Negi, A; Murphy, PV Development of Mcl-1 inhibitors for cancer therapy. Eur J Med Chem 210:0 (2021) [PubMed] 
Target
Name:
Bcl-2 homologous antagonist/killer
Synonyms:
Apoptosis regulator BAK | BAK | BAK1 | BAK_HUMAN | BCL2L7 | Bcl-2 homologous antagonist/killer | Bcl-2-like protein 7 | Bcl2-L-7 | CDN1
Type:
PROTEIN
Mol. Mass.:
23406.37
Organism:
Homo sapiens
Description:
ChEMBL_117067
Residue:
211
Sequence:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
  
Inhibitor
Name:
BDBM50591668
Synonyms:
CHEMBL5198484
Type:
Small organic molecule
Emp. Form.:
C36H35NO7
Mol. Mass.:
593.6656
SMILES:
[H][C@]12C[C@H](CCOC(=O)c3ccc(Oc4cccnc4)cc3)C=C[C@]1([C@H](\C=C(/C)c1ccc(cc1)C(O)=O)C=C(C)C2)C(O)=O |r,c:24,t:42|
Structure:
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