Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50165046
Substrate
n/a
Meas. Tech.
ChEMBL_304127 (CHEMBL840244)
EC50
>10000±n/a nM
Citation
 McKerrecher, D; Allen, JV; Bowker, SS; Boyd, S; Caulkett, PW; Currie, GS; Davies, CD; Fenwick, ML; Gaskin, H; Grange, E; Hargreaves, RB; Hayter, BR; James, R; Johnson, KM; Johnstone, C; Jones, CD; Lackie, S; Rayner, JW; Walker, RP Discovery, synthesis and biological evaluation of novel glucokinase activators. Bioorg Med Chem Lett 15:2103-6 (2005) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50165046
Synonyms:
6-(2-Benzyloxy-benzoylamino)-nicotinic acid | CHEMBL195299
Type:
Small organic molecule
Emp. Form.:
C20H16N2O4
Mol. Mass.:
348.352
SMILES:
OC(=O)c1ccc(NC(=O)c2ccccc2OCc2ccccc2)nc1
Structure:
Search PDB for entries with ligand similarity: