Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50592401
Substrate
n/a
Meas. Tech.
ChEMBL_2204086 (CHEMBL5116794)
Ki
126±n/a nM
Citation
 Zampieri, D; Fortuna, S; Romano, M; Amata, E; Dichiara, M; Marrazzo, A; Pasquinucci, L; Turnaturi, R; Mamolo, MG Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands. Bioorg Med Chem Lett 72:0 (2022) [PubMed] 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50592401
Synonyms:
CHEMBL5207122
Type:
Small organic molecule
Emp. Form.:
C24H28N2O3
Mol. Mass.:
392.4907
SMILES:
COc1ccc(CN(C)CCCNC(=O)c2ccc3ccccc3c2)cc1OC
Structure:
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