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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50165560
Substrate
n/a
Meas. Tech.
ChEMBL_305152 (CHEMBL832604)
IC50
180±n/a nM
Citation
 Tatsuta, M; Kataoka, M; Yasoshima, K; Sakakibara, S; Shogase, Y; Shimazaki, M; Yura, T; Li, Y; Yamamoto, N; Gupta, J; Urbahns, K Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives. Bioorg Med Chem Lett 15:2265-9 (2005) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50165560
Synonyms:
CHEMBL380576 | N-[1-Isopropyl-2-(2-methoxy-5-nitro-benzylsulfanyl)-1H-benzoimidazol-5-yl]-2,2-dimethyl-propionamide
Type:
Small organic molecule
Emp. Form.:
C23H28N4O4S
Mol. Mass.:
456.558
SMILES:
COc1ccc(cc1CSc1nc2cc(NC(=O)C(C)(C)C)ccc2n1C(C)C)[N+]([O-])=O
Structure:
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