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Target
Proteasome subunit beta type-1
Ligand
BDBM50593026
Substrate
n/a
Meas. Tech.
ChEMBL_2206760 (CHEMBL5119468)
IC50
114±n/a nM
Citation
 Wu, X; Sun, P; Chen, X; Hua, L; Cai, H; Liu, Z; Zhang, C; Liang, S; Chen, Y; Wu, D; Ou, Y; Hu, W; Yang, Z Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. J Med Chem 65:11985-12001 (2022) [PubMed] 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50593026
Synonyms:
CHEMBL5198837
Type:
Small organic molecule
Emp. Form.:
C21H25BF2N2O4
Mol. Mass.:
418.242
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1c(F)cccc1F)B(O)O |r|
Structure:
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