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Target
G protein-activated inward rectifier potassium channel 1
Ligand
BDBM50593401
Substrate
n/a
Meas. Tech.
ChEMBL_2208081 (CHEMBL5121030)
EC50
133±n/a nM
Citation
 Sharma, S; Lesiak, L; Aretz, CD; Du, Y; Kumar, S; Gautam, N; Alnouti, Y; Dhuria, NV; Chhonker, YS; Weaver, CD; Hopkins, CR Discovery, synthesis and biological characterization of a series of  RSC Med Chem 12:1366-1373 (2021) [PubMed] 
Target
Name:
G protein-activated inward rectifier potassium channel 1
Synonyms:
GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3
Type:
PROTEIN
Mol. Mass.:
56610.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107915
Residue:
501
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
  
Inhibitor
Name:
BDBM50593401
Synonyms:
CHEMBL5192503
Type:
Small organic molecule
Emp. Form.:
C15H17Cl2N3O2
Mol. Mass.:
342.22
SMILES:
CC(C)n1nc(C)cc1NC(=O)COc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: