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Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50167720
Substrate
n/a
Meas. Tech.
ChEMBL_305146 (CHEMBL832599)
IC50
>200000±n/a nM
Citation
 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 15:2865-9 (2005) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM50167720
Synonyms:
CHEMBL197151 | N-(4-Biphenyl-4-yl-oxazol-2-yl)-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C21H16N2O3S
Mol. Mass.:
376.428
SMILES:
O=S(=O)(Nc1nc(co1)-c1ccc(cc1)-c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: