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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50167724
Substrate
n/a
Meas. Tech.
ChEMBL_305145 (CHEMBL832598)
IC50
100000±n/a nM
Citation
 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 15:2865-9 (2005) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50167724
Synonyms:
CHEMBL372623 | N-[4-(4,5-Dimethyl-oxazol-2-ylsulfamoyl)-phenyl]-N-methyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C14H17N3O4S
Mol. Mass.:
323.367
SMILES:
CN(C(C)=O)c1ccc(cc1)S(=O)(=O)Nc1nc(C)c(C)o1
Structure:
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