Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase receptor R3
Ligand
BDBM518173
Substrate
n/a
Meas. Tech.
ChEMBL_2212883 (CHEMBL5125832)
IC50
10.0±n/a nM
Citation
Nguyen, MH; Atasoylu, O; Wu, L; Kapilashrami, K; Pusey, M; Gallagher, K; Lai, CT; Zhao, P; Barbosa, J; Liu, K; He, C; Zhang, C; Styduhar, ED; Witten, MR; Chen, Y; Lin, L; Yang, YO; Covington, M; Diamond, S; Yeleswaram, S; Yao, W Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2. ACS Med Chem Lett 13:1159-1164 (2022) [PubMed]
More Info.:
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1)
Type:
Enzyme
Mol. Mass.:
56134.46
Organism:
Homo sapiens (Human)
Description:
P37023
Residue:
503
Sequence:
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ