Reaction Details Report a problem with these data
Target
Mas-related G-protein coupled receptor member X2
Ligand
BDBM50594463
Substrate
n/a
Meas. Tech.
ChEMBL_2213078 (CHEMBL5126027)
IC50
2.5±n/a nM
Citation
 Sabnis, RW Novel MRGX2 Antagonists for Treating Diseases. ACS Med Chem Lett 13:1006-1007 (2022) [PubMed] 
Target
Name:
Mas-related G-protein coupled receptor member X2
Synonyms:
MRGPRX2 | MRGX2 | MRGX2_HUMAN | Mas-related G protein-coupled receptor X2 (MRGPRX2) | Mas-related G-protein coupled receptor member X2
Type:
GPCR
Mol. Mass.:
37104.79
Organism:
Homo sapiens (Human)
Description:
Q96LB1
Residue:
330
Sequence:
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
  
Inhibitor
Name:
BDBM50594463
Synonyms:
CHEMBL5184300
Type:
Small organic molecule
Emp. Form.:
C23H21F4N5O3
Mol. Mass.:
491.4382
SMILES:
C[C@H](N1CCC(F)(F)[C@H](C1)c1cc[n+]([O-])cc1)C(=O)Nc1cnc(Oc2ccc(F)cc2F)cn1 |r|
Structure:
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