Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50540057
Substrate
n/a
Meas. Tech.
ChEMBL_2215377 (CHEMBL5128509)
IC50
<300±n/a nM
Citation
 Wang, Y; Chen, H; Zha, X Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50540057
Synonyms:
CHEMBL4636862
Type:
Small organic molecule
Emp. Form.:
C31H39FN6O6S2
Mol. Mass.:
674.806
SMILES:
OC(=O)CCNC(=S)NCCCC[C@H](NS(=O)(=O)c1cccc(F)c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCC1 |r|
Structure:
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