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Target
Cholesteryl ester transfer protein
Ligand
BDBM50169284
Substrate
n/a
Meas. Tech.
ChEMBL_306246 (CHEMBL831156)
IC50
10000±n/a nM
Citation
 Brückner, D; Hafner, FT; Li, V; Schmeck, C; Telser, J; Vakalopoulos, A; Wirtz, G Dibenzodioxocinones--a new class of CETP inhibitors. Bioorg Med Chem Lett 15:3611-4 (2005) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50169284
Synonyms:
2-(2-Cyclopropyl-1-hydroxy-ethyl)-1-methoxy-8-methyl-6-(3-methyl-butoxy)-dibenzo[b,e][1,4]dioxepin-11-one | CHEMBL187790
Type:
Small organic molecule
Emp. Form.:
C25H30O6
Mol. Mass.:
426.5021
SMILES:
COc1c(ccc2Oc3c(OCCC(C)C)cc(C)cc3OC(=O)c12)C(O)CC1CC1
Structure:
Search PDB for entries with ligand similarity: