Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169500
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
704±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169500
Synonyms:
Butyl-ethyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL187923
Type:
Small organic molecule
Emp. Form.:
C26H31F3N4
Mol. Mass.:
456.5463
SMILES:
CCCCN(CC)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-3.88,3.65,;-4.3,2.16,;-3.21,1.06,;-1.72,1.46,;-.64,.35,;.84,.74,;1.24,2.23,;-1.06,-1.12,;.02,-2.22,;-.23,-3.75,;1.14,-4.47,;2.24,-3.38,;3.77,-3.15,;4.84,-4.24,;6.31,-3.85,;6.72,-2.37,;7.4,-4.94,;6.99,-6.43,;8.06,-7.52,;5.5,-6.82,;4.43,-5.72,;2.94,-6.1,;4.01,-1.64,;5.31,-.8,;5.24,.74,;3.87,1.43,;2.58,.6,;2.65,-.92,;1.54,-2,;-1.62,-4.43,;-2.86,-5.06,;-3.09,-3.78,;-1.97,-6,)|
Structure:
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