Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169502
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
653±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169502
Synonyms:
(2-Cyclopropyl-ethyl)-(2,2,2-trifluoro-ethyl)-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL188945
Type:
Small organic molecule
Emp. Form.:
C27H28F6N4
Mol. Mass.:
522.5284
SMILES:
Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CCC3CC3)CC(F)(F)F)c(nc12)C(F)(F)F |(9.19,-8.05,;8.11,-6.96,;6.62,-7.35,;5.55,-6.26,;4.06,-6.63,;5.95,-4.76,;7.45,-4.38,;7.84,-2.9,;8.52,-5.46,;4.88,-3.68,;5.14,-2.15,;6.43,-1.33,;6.36,.21,;4.99,.92,;3.69,.09,;3.76,-1.45,;2.67,-2.53,;1.13,-2.75,;.05,-1.66,;.47,-.17,;-.62,.93,;-2.11,.55,;-3.19,1.65,;-3.57,3.14,;-4.66,2.05,;1.94,.23,;2.35,1.7,;2.71,3.07,;3.82,2.35,;1.42,3.02,;.87,-4.27,;2.25,-5,;3.36,-3.9,;-.51,-4.97,;-1.97,-4.3,;-.86,-6.54,;-1.76,-5.6,)|
Structure:
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