Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169501
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
362±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169501
Synonyms:
(2-Cyclopropyl-ethyl)-propyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL188358
Type:
Small organic molecule
Emp. Form.:
C28H33F3N4
Mol. Mass.:
482.5836
SMILES:
CCCN(CCC1CC1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-.16,-1.38,;-1.65,-1.77,;-2.05,-3.25,;-3.54,-3.64,;-4.62,-2.54,;-4.21,-1.06,;-5.28,.04,;-5.68,1.53,;-6.78,.46,;-3.95,-5.13,;-2.87,-6.22,;-3.12,-7.75,;-1.75,-8.47,;-.64,-7.37,;.89,-7.16,;1.96,-8.24,;3.43,-7.86,;3.85,-6.37,;4.52,-8.94,;4.11,-10.43,;5.18,-11.52,;2.62,-10.82,;1.55,-9.73,;.05,-10.1,;1.13,-5.63,;2.43,-4.8,;2.36,-3.26,;.99,-2.55,;-.3,-3.39,;-.23,-4.92,;-1.34,-6,;-4.51,-8.44,;-5.76,-9.07,;-5.98,-7.77,;-4.86,-10.01,)|
Structure:
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