Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169503
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
2774.0±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169503
Synonyms:
Benzyl-ethyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL362567
Type:
Small organic molecule
Emp. Form.:
C29H29F3N4
Mol. Mass.:
490.5626
SMILES:
CCN(Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F)Cc1ccccc1 |(.5,-13.42,;.1,-14.89,;-1.39,-15.29,;-1.8,-16.78,;-.72,-17.87,;-.97,-19.4,;.4,-20.12,;1.5,-19.02,;3.04,-18.81,;4.11,-19.89,;3.69,-21.38,;2.2,-21.75,;4.77,-22.48,;6.26,-22.08,;7.35,-23.18,;6.68,-20.59,;5.6,-19.51,;6,-18.02,;3.29,-17.27,;4.58,-16.45,;4.51,-14.91,;3.13,-14.19,;1.85,-15.03,;1.92,-16.57,;.82,-17.65,;-2.36,-20.09,;-3.61,-20.72,;-3.83,-19.42,;-2.72,-21.66,;-2.47,-14.19,;-3.96,-14.57,;-5.03,-13.47,;-6.53,-13.86,;-6.93,-15.34,;-5.85,-16.43,;-4.36,-16.05,)|
Structure:
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