Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169508
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
20±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169508
Synonyms:
CHEMBL424812 | Cyclopropylmethyl-[2-methyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C27H34N4
Mol. Mass.:
414.5857
SMILES:
CCCN(CC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 |(-9.52,5.06,;-8.46,3.94,;-8.86,2.47,;-7.77,1.35,;-6.29,1.74,;-5.88,3.24,;-4.78,4.31,;-6.27,4.71,;-8.18,-.12,;-7.11,-1.22,;-7.37,-2.76,;-8.74,-3.44,;-5.99,-3.48,;-4.88,-2.39,;-3.35,-2.15,;-2.28,-3.25,;-2.68,-4.74,;-4.18,-5.12,;-1.61,-5.83,;-.12,-5.44,;.96,-6.54,;.29,-3.95,;-.79,-2.85,;-.39,-1.38,;-3.1,-.64,;-1.8,.2,;-1.87,1.74,;-3.24,2.44,;-4.54,1.61,;-4.47,.09,;-5.57,-1,)|
Structure:
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