Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169511
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
75±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169511
Synonyms:
(2,2,3,3,3-Pentafluoro-propyl)-propyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL360000
Type:
Small organic molecule
Emp. Form.:
C26H26F8N4
Mol. Mass.:
546.4987
SMILES:
CCCN(Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F)CC(F)(F)C(F)(F)F |(-2.7,3.33,;-4.19,2.93,;-4.59,1.45,;-6.08,1.06,;-6.5,-.43,;-5.41,-1.52,;-5.66,-3.05,;-4.29,-3.76,;-3.19,-2.68,;-1.65,-2.46,;-.58,-3.54,;.89,-3.15,;1.31,-1.66,;1.98,-4.24,;1.57,-5.73,;2.64,-6.83,;.08,-6.11,;-.99,-5.02,;-2.49,-5.41,;-1.41,-.93,;-.11,-.1,;-.18,1.44,;-1.55,2.14,;-2.84,1.32,;-2.77,-.22,;-3.88,-1.29,;-7.05,-3.74,;-8.52,-3.08,;-7.4,-5.3,;-8.31,-4.37,;-7.16,2.16,;-6.75,3.65,;-5.99,4.98,;-5.27,3.26,;-7.82,4.75,;-9.43,4.59,;-8.8,5.75,;-7.65,6.34,)|
Structure:
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