Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169510
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
370±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169510
Synonyms:
CHEMBL363218 | Cyclopropylmethyl-[9-(2,4-dichloro-phenyl)-2-trifluoromethyl-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H23Cl2F3N4
Mol. Mass.:
495.367
SMILES:
CCCN(CC1CC1)Cc1c(nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n12)C(F)(F)F |(6.95,3.42,;5.46,3.03,;5.04,1.55,;3.57,1.16,;2.48,2.26,;2.89,3.75,;3.97,4.82,;2.5,5.22,;3.16,-.33,;4.23,-1.42,;3.97,-2.95,;5.35,-3.67,;6.46,-2.57,;7.98,-2.35,;9.05,-3.44,;8.65,-4.93,;9.72,-6.02,;11.22,-5.63,;12.3,-6.72,;11.62,-4.13,;10.55,-3.05,;10.94,-1.57,;8.24,-.82,;9.54,,;9.47,1.54,;8.09,2.25,;6.79,1.41,;6.86,-.12,;5.77,-1.2,;2.6,-3.64,;1.34,-4.27,;1.13,-2.97,;2.24,-5.21,)|
Structure:
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