Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169515
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
75±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169515
Synonyms:
CHEMBL189115 | Propyl-(2,2,2-trifluoro-ethyl)-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C25H26F6N4
Mol. Mass.:
496.4912
SMILES:
CCCN(Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F)CC(F)(F)F |(-2.65,3.67,;-4.14,3.28,;-4.54,1.79,;-6.03,1.41,;-6.43,-.08,;-5.35,-1.17,;-5.61,-2.7,;-4.23,-3.41,;-3.14,-2.33,;-1.6,-2.11,;-.53,-3.19,;-.95,-4.67,;-2.44,-5.06,;.12,-5.76,;1.62,-5.38,;2.7,-6.48,;2.04,-3.89,;.96,-2.8,;1.36,-1.31,;-1.35,-.58,;-.06,.25,;-.13,1.79,;-1.51,2.49,;-2.79,1.67,;-2.72,.13,;-3.82,-.94,;-6.99,-3.39,;-8.46,-2.73,;-7.36,-4.95,;-8.24,-4.02,;-7.1,2.51,;-6.7,4,;-6.32,5.34,;-5.22,4.64,;-7.64,5.31,)|
Structure:
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