Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169521
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
7708±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169521
Synonyms:
Benzyl-butyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL190823
Type:
Small organic molecule
Emp. Form.:
C31H33F3N4
Mol. Mass.:
518.6157
SMILES:
CCCCN(Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F)Cc1ccccc1 |(1.93,-.05,;1.52,-1.52,;.03,-1.92,;-.37,-3.4,;-1.86,-3.78,;-2.28,-5.28,;-1.19,-6.37,;-1.45,-7.9,;-.07,-8.61,;1.03,-7.53,;2.56,-7.3,;3.64,-8.39,;3.22,-9.87,;1.73,-10.26,;4.3,-10.96,;5.79,-10.58,;6.86,-11.68,;6.2,-9.09,;5.11,-8,;5.52,-6.51,;2.8,-5.78,;4.11,-4.95,;4.04,-3.41,;2.66,-2.7,;1.38,-3.53,;1.45,-5.07,;.33,-6.14,;-2.84,-8.59,;-4.08,-9.21,;-4.3,-7.92,;-3.19,-10.15,;-2.94,-2.69,;-4.43,-3.08,;-5.5,-1.97,;-6.98,-2.36,;-7.4,-3.85,;-6.31,-4.94,;-4.82,-4.55,)|
Structure:
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