Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169522
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
250±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169522
Synonyms:
CHEMBL188623 | Phenethyl-propyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C31H33F3N4
Mol. Mass.:
518.6157
SMILES:
CCCN(CCc1ccccc1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(6.83,3.63,;5.34,3.24,;4.93,1.76,;3.45,1.37,;2.36,2.47,;2.77,3.96,;1.7,5.05,;.22,4.66,;-.86,5.75,;-.46,7.24,;1.03,7.62,;2.11,6.54,;3.04,-.12,;4.11,-1.21,;3.85,-2.74,;5.23,-3.46,;6.34,-2.36,;7.87,-2.14,;8.94,-3.23,;10.43,-2.84,;10.83,-1.36,;11.5,-3.92,;11.1,-5.42,;12.18,-6.51,;9.61,-5.81,;8.53,-4.72,;7.04,-5.09,;8.12,-.61,;9.42,.21,;9.35,1.75,;7.97,2.46,;6.68,1.62,;6.75,.09,;5.65,-.99,;2.48,-3.43,;1.22,-4.06,;1.01,-2.76,;2.12,-5,)|
Structure:
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