Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169529
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
59±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169529
Synonyms:
CHEMBL360185 | Cyclopropylmethyl-[6-fluoro-2-methyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C27H33FN4
Mol. Mass.:
432.5761
SMILES:
CCCN(CC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 |(3.81,5.27,;4.89,4.17,;4.49,2.68,;5.56,1.58,;7.06,1.98,;7.45,3.45,;8.55,4.53,;7.07,4.94,;5.16,.09,;6.24,-1,;5.98,-2.53,;4.6,-3.22,;7.36,-3.25,;8.46,-2.16,;10,-1.94,;11.07,-3.02,;12.56,-2.64,;12.96,-1.15,;13.64,-3.72,;13.22,-5.21,;14.31,-6.31,;11.73,-5.61,;10.65,-4.51,;9.16,-4.89,;10.25,-.4,;11.54,.42,;11.47,1.96,;10.09,2.68,;10.02,4.22,;8.81,1.84,;8.88,.3,;7.77,-.78,)|
Structure:
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