Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169523
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
34±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169523
Synonyms:
CHEMBL427527 | Cyclopropylmethyl-(2,2,3,3,3-pentafluoro-propyl)-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C27H26F8N4
Mol. Mass.:
558.5094
SMILES:
Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CC3CC3)CC(F)(F)C(F)(F)F)c(nc12)C(F)(F)F |(3.76,-7.28,;2.69,-6.18,;3.1,-4.69,;2.01,-3.61,;2.42,-2.13,;.54,-3.99,;.12,-5.49,;-1.37,-5.86,;1.2,-6.58,;-.54,-2.91,;-.3,-1.38,;1.01,-.56,;.94,.98,;-.44,1.69,;-1.72,.85,;-1.65,-.68,;-2.77,-1.76,;-4.29,-1.98,;-5.38,-.89,;-4.96,.6,;-3.47,.99,;-3.07,2.47,;-3.47,3.95,;-1.97,3.54,;-6.04,1.7,;-5.63,3.19,;-4.55,4.28,;-7.12,2.79,;-6.71,4.28,;-8.31,4.14,;-7.68,5.28,;-6.53,5.89,;-4.55,-3.5,;-3.17,-4.23,;-2.07,-3.13,;-5.94,-4.2,;-7.4,-3.53,;-6.29,-5.77,;-7.18,-4.82,)|
Structure:
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