Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169524
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
23±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169524
Synonyms:
CHEMBL186628 | Cyclopropylmethyl-propyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C27H31F3N4
Mol. Mass.:
468.557
SMILES:
CCCN(CC1CC1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-2.56,-11.8,;-1.49,-12.89,;-1.88,-14.38,;-.81,-15.48,;.68,-15.09,;1.08,-13.61,;.7,-12.12,;2.18,-12.53,;-1.21,-16.97,;-.13,-18.07,;-.39,-19.59,;.99,-20.32,;2.09,-19.22,;3.63,-19,;4.7,-20.08,;6.19,-19.7,;6.59,-18.21,;7.27,-20.78,;6.85,-22.28,;7.94,-23.37,;5.35,-22.67,;4.28,-21.58,;2.79,-21.95,;3.86,-17.47,;5.17,-16.64,;5.1,-15.1,;3.72,-14.39,;2.44,-15.23,;2.51,-16.76,;1.4,-17.84,;-1.77,-20.28,;-3.03,-20.91,;-3.24,-19.61,;-2.14,-21.86,)|
Structure:
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