Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169538
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
1412±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169538
Synonyms:
(2-Cyclopropyl-ethyl)-ethyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL187815
Type:
Small organic molecule
Emp. Form.:
C27H31F3N4
Mol. Mass.:
468.557
SMILES:
CCN(CCC1CC1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(.75,2.7,;.33,1.23,;-1.14,.83,;-2.23,1.94,;-3.72,1.55,;-4.8,2.65,;-5.18,4.14,;-6.27,3.05,;-1.55,-.65,;-.48,-1.75,;-.74,-3.27,;.64,-4,;1.75,-2.9,;3.27,-2.68,;4.34,-3.76,;5.84,-3.38,;6.23,-1.9,;6.91,-4.46,;6.51,-5.95,;7.59,-7.05,;5.01,-6.35,;3.94,-5.25,;2.45,-5.63,;3.53,-1.15,;4.83,-.33,;4.76,1.21,;3.38,1.93,;2.08,1.09,;2.15,-.44,;1.06,-1.52,;-2.11,-3.96,;-3.37,-4.59,;-3.58,-3.3,;-2.47,-5.53,)|
Structure:
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