Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169532
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
3560±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169532
Synonyms:
2-Trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazole-3-carboxylic acid cyclopropylmethyl-propyl-amide | CHEMBL433763
Type:
Small organic molecule
Emp. Form.:
C27H29F3N4O
Mol. Mass.:
482.5406
SMILES:
CCCN(CC1CC1)C(=O)c1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-6.76,4.88,;-5.68,3.78,;-6.08,2.3,;-5.01,1.19,;-3.51,1.58,;-3.12,3.07,;-3.5,4.54,;-2.02,4.14,;-5.41,-.29,;-6.9,-.68,;-4.33,-1.38,;-4.59,-2.92,;-3.21,-3.64,;-2.11,-2.55,;-.58,-2.32,;.5,-3.41,;.08,-4.9,;-1.42,-5.28,;1.15,-5.99,;2.64,-5.61,;3.73,-6.7,;3.06,-4.11,;1.98,-3.02,;2.39,-1.54,;-.33,-.8,;.96,.04,;.89,1.58,;-.48,2.28,;-1.76,1.45,;-1.7,-.08,;-2.8,-1.17,;-5.97,-3.6,;-7.22,-4.23,;-7.44,-2.95,;-6.34,-5.18,)|
Structure:
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