Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169534
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
249±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169534
Synonyms:
CHEMBL187362 | Ethyl-phenethyl-[2-trifluoromethyl-9-(2,4,6-trimethyl-phenyl)-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C30H31F3N4
Mol. Mass.:
504.5891
SMILES:
CCN(CCc1ccccc1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-2.39,-.03,;-2.8,-1.52,;-4.28,-1.9,;-5.36,-.8,;-4.96,.69,;-6.03,1.79,;-7.52,1.39,;-8.6,2.49,;-8.2,3.98,;-6.71,4.35,;-5.63,3.26,;-4.7,-3.39,;-3.61,-4.48,;-3.87,-6.01,;-2.49,-6.72,;-1.39,-5.64,;.14,-5.42,;1.21,-6.5,;.8,-7.98,;-.69,-8.37,;1.87,-9.08,;3.36,-8.69,;4.44,-9.79,;3.78,-7.2,;2.69,-6.12,;3.1,-4.62,;.38,-3.89,;1.69,-3.06,;1.62,-1.52,;.24,-.82,;-1.05,-1.64,;-.98,-3.18,;-2.09,-4.25,;-5.26,-6.7,;-6.5,-7.33,;-6.73,-6.04,;-5.61,-8.26,)|
Structure:
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