Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50169539
Substrate
n/a
Meas. Tech.
ChEMBL_303113 (CHEMBL829622)
Ki
240±n/a nM
Citation
 Han, X; Pin, SS; Burris, K; Fung, LK; Huang, S; Taber, MT; Zhang, J; Dubowchik, GM Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists. Bioorg Med Chem Lett 15:4029-32 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50169539
Synonyms:
Bis-cyclopropylmethyl-[9-(2,4-dichloro-phenyl)-2-trifluoromethyl-9H-benzo[d]imidazo[1,2-a]imidazol-3-ylmethyl]-amine | CHEMBL364537
Type:
Small organic molecule
Emp. Form.:
C25H23Cl2F3N4
Mol. Mass.:
507.378
SMILES:
FC(F)(F)c1nc2n(-c3ccc(Cl)cc3Cl)c3ccccc3n2c1CN(CC1CC1)CC1CC1 |(-.09,-3.94,;1.15,-3.31,;-.32,-2.64,;.8,-4.88,;2.54,-2.62,;3.91,-3.34,;5.02,-2.24,;6.55,-2.03,;7.62,-3.11,;7.21,-4.6,;8.28,-5.69,;9.77,-5.3,;10.84,-6.39,;10.18,-3.8,;9.09,-2.73,;9.5,-1.24,;6.79,-.5,;8.09,.33,;8.02,1.86,;6.65,2.58,;5.36,1.74,;5.43,.21,;4.32,-.87,;2.8,-1.09,;1.71,,;2.13,1.48,;1.05,2.59,;1.45,4.07,;2.55,5.14,;1.06,5.56,;3.61,1.88,;4.01,3.35,;5.11,4.43,;3.62,4.84,)|
Structure:
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