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Target
Integrase
Ligand
BDBM50169889
Substrate
n/a
Meas. Tech.
ChEMBL_305216 (CHEMBL832469)
IC50
80000±n/a nM
Citation
 Meadows, DC; Mathews, TB; North, TW; Hadd, MJ; Kuo, CL; Neamati, N; Gervay-Hague, J Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors. J Med Chem 48:4526-34 (2005) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50169889
Synonyms:
3-Methoxy-5-[(E)-2-((E)-2-phenyl-ethenesulfonylmethanesulfonyl)-vinyl]-benzene-1,2-diol | CHEMBL191022
Type:
Small organic molecule
Emp. Form.:
C18H18O7S2
Mol. Mass.:
410.461
SMILES:
COc1cc(\C=C\S(=O)(=O)CS(=O)(=O)\C=C\c2ccccc2)cc(O)c1O
Structure:
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