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Target
Adenosine receptor A2b
Ligand
BDBM50170137
Substrate
n/a
Meas. Tech.
ChEMBL_312875 (CHEMBL874953)
IC50
400±n/a nM
Citation
 Baraldi, PG; Preti, D; Tabrizi, MA; Fruttarolo, F; Romagnoli, R; Zaid, NA; Moorman, AR; Merighi, S; Varani, K; Borea, PA New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. J Med Chem 48:4697-701 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50170137
Synonyms:
1-Benzyl-7-methyl-3-propyl-1H,6H-pyrrolo[2,1-f]purine-2,4-dione | 1-benzyl-7-methyl-3-propyl-1H-pyrrolo[1,2-a]purine-2,4(3H,6H)-dione | CHEMBL189904
Type:
Small organic molecule
Emp. Form.:
C19H20N4O2
Mol. Mass.:
336.3877
SMILES:
CCCn1c(=O)n(Cc2ccccc2)c2nc3C=C(C)Cn3c2c1=O |t:18|
Structure:
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