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Target
Collagenase 3
Ligand
BDBM50170297
Substrate
n/a
Meas. Tech.
ChEMBL_305658 (CHEMBL829516)
IC50
35±n/a nM
Citation
Wu, J; Rush, TS; Hotchandani, R; Du, X; Geck, M; Collins, E; Xu, ZB; Skotnicki, J; Levin, JI; Lovering, FE Identification of potent and selective MMP-13 inhibitors. Bioorg Med Chem Lett 15:4105-9 (2005) [PubMed] Article
More Info.:
Target
Name:
Collagenase 3
Synonyms:
MMP13 | MMP13_BOVIN | Matrix metalloproteinase 13
Type:
PROTEIN
Mol. Mass.:
53910.47
Organism:
Bos taurus
Description:
ChEMBL_305658
Residue:
471
Sequence:
MHPRVLAGFLFFSWTACWSLPLPSDGDSEDLSEEDFQFAESYLKSYYYPQNPAGILKKTAASSVIDRLREMQSFFGLEVTGRLDDNTLDIMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDLTHSEVEKAFRKAFKVWSDVTPLNFTRIHNGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPYSKHPKTPDKCDPSLSLDAITSLRGETLIFKDRFFWRLHPQQVEAELFLTKSFGPELPNRIDAAYEHPSHDLIFIFRGRKFWALSGYDILEDYPKKISELGFPKHVKKISAALHFEDSGKTLFFSENQVWSYDDTNHVMDKDYPRLIEEVFPGIGDKVDAVYQKNGYIYFFNGPIQFEYSIWSNRIVRVMTTNSLLWC
Inhibitor
Name:
BDBM50170297
Synonyms:
(S)-2-{4'-[(1H-Indole-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | CHEMBL189666
Type:
Small organic molecule
Emp. Form.:
C26H25N3O5S
Mol. Mass.:
491.559
SMILES:
CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3[nH]2)cc1)C(O)=O