Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50170839
Substrate
n/a
Meas. Tech.
ChEMBL_303319 (CHEMBL840044)
Ki
5400±n/a nM
Citation
 Perreira, M; Jiang, JK; Klutz, AM; Gao, ZG; Shainberg, A; Lu, C; Thomas, CJ; Jacobson, KA "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem 48:4910-8 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50170839
Synonyms:
CHEMBL187794 | N*2*-Biphenyl-4-yl-N*6*-cyclohexyl-9H-purine-2,6-diamine
Type:
Small organic molecule
Emp. Form.:
C23H24N6
Mol. Mass.:
384.4769
SMILES:
C1CCC(CC1)Nc1nc(Nc2ccc(cc2)-c2ccccc2)nc2nc[nH]c12
Structure:
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