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Target
Kappa-type opioid receptor
Ligand
BDBM50595846
Substrate
n/a
Meas. Tech.
ChEMBL_2218136 (CHEMBL5131268)
EC50
26±n/a nM
Citation
 Stefanucci, A; Della Valle, A; Scioli, G; Marinaccio, L; Pieretti, S; Minosi, P; Szucs, E; Benyhe, S; Masci, D; Tanguturi, P; Chou, K; Barlow, D; Houseknecht, K; Streicher, JM; Mollica, A Discovery of ? Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved  ACS Med Chem Lett 13:1707-1714 (2022) [PubMed] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50595846
Synonyms:
CHEMBL5183917
Type:
Small organic molecule
Emp. Form.:
C30H44N8O4
Mol. Mass.:
580.7216
SMILES:
CCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@H](CCCNC(N)=N)C(N)=O |r|
Structure:
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