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Target
Cyclin-dependent kinase 7
Ligand
BDBM50595929
Substrate
n/a
Meas. Tech.
ChEMBL_2218552 (CHEMBL5131886)
IC50
71±n/a nM
Citation
 Raghuvanshi, R; Bharate, SB Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. J Med Chem 65:893-921 (2022) [PubMed] 
Target
Name:
Cyclin-dependent kinase 7
Synonyms:
39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:
Enzyme Subunit
Mol. Mass.:
39047.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
  
Inhibitor
Name:
BDBM50595929
Synonyms:
CHEMBL5193007
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N4O3
Mol. Mass.:
473.352
SMILES:
CC(C)c1[nH]n(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)nc(=O)c12 |(-4.67,-4.75,;-5.7,-3.6,;-7.21,-3.92,;-5.23,-2.14,;-6.13,-.89,;-5.23,.35,;-5.7,1.82,;-4.67,2.96,;-3.17,2.64,;-5.15,4.43,;-6.66,4.75,;-7.69,3.6,;-7.21,2.14,;-8.24,.99,;-3.76,-.12,;-2.43,.65,;-1.1,-.12,;.24,.65,;1.57,-.12,;1.57,-1.66,;2.91,-2.43,;4.24,-1.66,;5.57,-2.43,;6.91,-1.66,;6.91,-.12,;8.24,.65,;4.24,-.12,;2.91,.65,;-1.1,-1.66,;-2.43,-2.43,;-2.43,-3.97,;-3.76,-1.66,)|
Structure:
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