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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50596052
Substrate
n/a
Meas. Tech.
ChEMBL_2219158 (CHEMBL5132492)
Kd
28±n/a nM
Citation
 Prakash, M; Itoh, Y; Fujiwara, Y; Takahashi, Y; Takada, Y; Mellini, P; Elboray, EE; Terao, M; Yamashita, Y; Yamamoto, C; Yamaguchi, T; Kotoku, M; Kitao, Y; Singh, R; Roy, R; Obika, S; Oba, M; Wang, DO; Suzuki, T Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach. J Med Chem 64:15810-15824 (2021) [PubMed] 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50596052
Synonyms:
CHEMBL5196484
Type:
Small organic molecule
Emp. Form.:
C23H18Cl2N6O6
Mol. Mass.:
545.332
SMILES:
Cc1c(Nc2ccncc2C(=O)NNC(=O)\C=C\C(O)=O)cc(Cl)c(Nc2ccccc2[N+]([O-])=O)c1Cl
Structure:
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