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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50596239
Substrate
n/a
Meas. Tech.
ChEMBL_2219913 (CHEMBL5133247)
IC50
>10000±n/a nM
Citation
 Bender, AM; Carter, TR; Spock, M; Rodriguez, AL; Dickerson, JW; Rook, JM; Chang, S; Qi, A; Presley, CC; Engers, DW; Harp, JM; Bridges, TM; Niswender, CM; Conn, PJ; Lindsley, CW Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M Bioorg Med Chem Lett 56:0 (2022) [PubMed] 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60161.80
Organism:
RAT
Description:
Cholinergic, muscarinic M5 CHRM5 RAT::P08911
Residue:
531
Sequence:
MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50596239
Synonyms:
CHEMBL5189893
Type:
Small organic molecule
Emp. Form.:
C26H35N5O2
Mol. Mass.:
449.5884
SMILES:
CC(=O)Nc1ccc(cc1)-c1ccc(NC[C@@H]2CC22CCN(CC3CCOCC3)CC2)nn1 |r|
Structure:
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