Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50172004
Substrate
n/a
Meas. Tech.
ChEMBL_310805 (CHEMBL824856)
EC50
<1±n/a nM
Citation
 Shi, GQ; Dropinski, JF; Zhang, Y; Santini, C; Sahoo, SP; Berger, JP; Macnaul, KL; Zhou, G; Agrawal, A; Alvaro, R; Cai, TQ; Hernandez, M; Wright, SD; Moller, DE; Heck, JV; Meinke, PT Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity. J Med Chem 48:5589-99 (2005) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA | PPARA_CANLF
Type:
PROTEIN
Mol. Mass.:
52119.89
Organism:
Canis familiaris
Description:
ChEMBL_796444
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFSFTEYQYLGSGPGSDGSVITDTLSPAPSPSSVTHPAAPGGAEEPSSVALNIECRICGDRASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEQDPEDAETADLKSLAKRIYEAYLKNFNMNKVKARVILAGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKSIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLKLHLQTNHPDNIFLFPKLLQKMADLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50172004
Synonyms:
(S)-5-{3-[2-Chloro-4-(2,2,2-trifluoro-ethyl)-phenoxy]-propoxy}-2-ethyl-2,3-dihydro-benzofuran-2-carboxylic acid | CHEMBL189110
Type:
Small organic molecule
Emp. Form.:
C22H22ClF3O5
Mol. Mass.:
458.855
SMILES:
CC[C@]1(Cc2cc(OCCCOc3ccc(CC(F)(F)F)cc3Cl)ccc2O1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: