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Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50172191
Substrate
n/a
Meas. Tech.
ChEMBL_321183 (CHEMBL882912)
IC50
30±n/a nM
Citation
 Liu, W; Chen, S; Dropinski, J; Colwell, L; Robins, M; Szymonifka, M; Hayes, N; Sharma, N; MacNaul, K; Hernandez, M; Burton, C; Sparrow, CP; Menke, JG; Singh, SB Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis. Bioorg Med Chem Lett 15:4574-8 (2005) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50172191
Synonyms:
3-[((4S,4aR)-6-Hydroxy-4a-methyl-1-(S)-methyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carbonyl)-amino]-adamantane-1-carboxylic acid ethyl ester | CHEMBL196335
Type:
Small organic molecule
Emp. Form.:
C30H41NO4
Mol. Mass.:
479.6508
SMILES:
CCOC(=O)C12CC3CC(CC(C3)(C1)NC(=O)[C@@]1(C)CCC[C@@]3(C)[C@H]1CCc1ccc(O)cc31)C2 |TLB:8:9:13:6.7.12,3:5:10:7.12.8,THB:8:7:13:34.9.10,6:5:10:7.12.8,6:7:5.13.34:10|
Structure:
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